Unguentum Nistatini 1000000 ED/g

International Nonproprietary name

Nystatin.

Pharmatherapeutic Group

Antifungal drug.

Farmacoceutical Formulation

1 g of  ointment contains 100000 units of nystatin.

Pharmacological Action

Pharmacodynamics

Nystatin has an antifungal, fungistatic, fungicidal action.

Nystatin relates to polyene antibiotic group. It’s structure has molecules with big quantities of double bonds, stipulating for high tropicity of agent to stearic formations of thyroplasma membrane of fungus. As a result molecule is embedded into the cell membrane with formation of a quantity of channels promoting to  uncontrolled transport of water, electrolytes and nonelectrolytes. The cell losses resistance to attacks of outside osmotic forces and is lysed. Nystatin is active to yeast-like fungus of Candida and Aspergillus generation.

Tolerance progress to nystatin of sensitive fungus is very slow.

Pharmacokinetics

At external and local administration the preparation is not absorbed through cutaneous integument or mucous membranes.

Therapeutic Indications

Nistatin ointment is used at candidosis of mucous tunic of oral cavity, genital organs, gastrointestinal tract, skin.  

Direction for Use and Dosage Schedule

At curing cutaneous mycoses and mucous membranes the ointment is applied with thin layer onto affected areas 1-2 times a day, every day within 7-10 days. Application of ointment may be combined with nistatin intake.

Particular Indications

At fungus infection of vagina it is recommended to conduct a simultaneous treatment of sexual partner. During treatment sexual contacts should be avoided.

Adverse Reaction

Using of nistatin ointment may cause allergic reactions such as skin itch and appearance of skin rash,hyperemia in the place of ointment application. In such cases the drug should be withdrawn and desensitizing therapy will be conducted.

Contraindications

Increased individual sensitivity to the preparation.

Interaction with other drugs

At simultaneous using of nistatin with clotrymasol the activity of the latter is lowered.

Form of  Production

Ointment ( nistatin content – 100000 UNITS in 1 g). Gallipots containing 15, 25, 30 g or tubes containing 15, 25, 30 g.