Proxodolol (solution 1% (eye drops))

Proxodololum

International unlicensed name

Proxodolol.

Pharmacotherapy group

Alpha- and beta-adrenolytic agents.

Composition

1 ml of eye drops contains proxodolol 10 mg.

Pharmacological action

Pharmacodynamics

Proxodolol is nonselective b-adrenoblocker combining blocking action onto b-1,2 and a-adrenoreceptors. The preparation reduces intraocular pressure that is provided by the reduction in aqueous humor production and facilitation of its outflow. The effects starts in 15—30 minutes after instillation and its maximum is achieved in 4—6 hours. The preparation does not change the pupil diameter and eye accommodation, does not irritate the eye.

Pharmacokinetics

On local administration proxodolol penetrated rapidly through the cornea into the eye tissues. It gets into systemic blood flow in small quantities.

Indication

Proxodolol is used for reduction of intraocular pressure on primary angle-open and angle-closed glaucoma, on secondary glaucoma, on insufficient effect after antiglaucoma operations.

Route and dosage

In the beginning of the treatment proxodolol solution 1% is prescribed, and when necessary, one can switch to proxodolol solution 2%. Proxodolol solution 1% or 2% is instilled into the conjunctival sac 1—2 drops 2—3 times a day.

Side effects

The following case are possible: cardiac rhythm delay, reduction of systemic blood pressure (due to adrenoblocking action) and bronchospasmodic effect.

Contraindications

Instillation with proxodolol is contraindicated in patients with bronchial asthma, chronic obstructive lung diseases, heart failure, marked bradycardia.

Interaction with other medications

The preparation can be used in combination with pilocarpine and/or clonidine drops.

Product form

Solution 1% (eye drops). 1 ml in a drop-tube. 5 in a phial. 2, 5 or 10 drop tubes in a package or 2 drop tubes in a blister.