Acetylsalicylic acid
(freeze-dried powder for preparation of solution for injections, 0,25 gand 0,05 g)
Acidum acetylsalicylicum 0,25 et 0,05
International nonproprietary name
Acetylsalicylic acid.
Pharmacotherapeutic group
Nonsteroid antiinflammatory drugs. Preparations for treatment of eye diseases.
Composition of the preparation
1 vial contains freeze-driedpowder of acetylsalicylic acid: 25 mg or 50 mg.
Pharmacological action
Pharmacodynamics
Acetylsalicylic acid is nonsteroid antiinflammatory drug with antipyretic, analgesic, anti-inflammatory, antiaggregatory action. Inhibits cyclooxygenase and irreversibly inhibits cyclooxygenase way of arachidonic acid metabolism. Influences on subcortical centers of thermoregulation and pain sensitivity. Reduces hyperemia, exudation, capillary permeability, activity of hyaluronidase, limits energy provision of inflammatory process by ATP production inhibition. Decrease of ТхВ2 contentsin thrombocytes that leads to irreversible suppression of aggregation. Slightly dilates vessels. Considerable inhibition of platelets sticking is reached at doses up to 30 mg.
Pharmakokinetics
After parenteral introduction Acetylsalicylic acid is very quickly hydrolyzed by esterases (Т1/2is no more than 15-20 min). Anion of Acetylsalicylic acidcirculates in an organism. Salicylates easily enter into tissues and liquids of an organism, diffusion is accelerated at hyperemia and edema, becomes slower in proliferative phase of an inflammation. Salicylates get through a placenta, in small amounts are excreted with breast milk. They biotransformed in a liver with formation of 4 metabolites; excreted by kidneys (the excretion is considerably increased at alkalization of urine).
Indications
Inflammatory processes in eye of various origin and localization: endogenous and exogenous uveites, including traumatic, postoperative, contusional, burn uveites; keratites, sclerites, keratouveitis, conjunctivitises. The anti-inflammatory effect is most expressed at preparation use in the acute period of inflammatory process in eye at the perforated and combined traumas of organ of vision. The preparation stops consensual irritation of paired intact eye.
Dosage and method of administration
Add 0,025 gor 0,05 g of the preparation to the content of an ampoule with of 2,5 ml or 5 ml injection solution, respectively, and stir up to complete dissolution. The received 1 % solution of acetylsalicylic acid should be used within a day. The solution is entered under conjunctiva or in a parabulbar way in a dose not more than 0,5 ml, daily or every other day. It is necessary to make from 5 to 10 injections for the course of treatment. For decrease of painfulness of injections add 0,2 - 0,3 ml of 1 % or 2 % Novocain solution in a syringe.
The solution can be used in the form of instillations per 1 - 2 drops 3 - 4 times a day.
Side effects
Side effects, as a rule, are not observed at observance of the instruction on preparation application. Tissue edema, subconjunctival hemorrhage can sometimes be observed in the place of injections.
Contraindications
Hypersensitivity to acetylsalicylic acid.
Interactions with other medicinal preparations
The acetylsalicylic acid increases heparin action. It should not be administrated with other nonsteroid antiinflammatory drugs. It is not necessary to mix injection solution of the preparation with solutions of other medical products. Compatible with Novocain
Overdosage
The overdosage is possible at single introduction of excessively high doses of the preparation or at long application.
Signs:nausea, vomiting, sonitus, malaise, fever.
Treatment:symptomatic, urine alkalization, diuresis induction.
The form of release
Powder for preparation of injection solution per 25 or 50 mg in vials or ampoules. 5 or 10 vials or ampoules in a pack, 5 ampoules in a blister.
